Substituted indole compounds with Inhibitory activity of nos. Pharmaceutical compositions.

摘要

Pharmaceutical compositions containing same.Claim 1: a compound with the formula (1), or one of its pharmaceutically acceptable salts or prodrugs, where r1es h, alkyl, optionally substituted C1 - 6, alcarilo c1-4 optionally replaced, or alcaheterociclilo c1-4 optionally substituted; each of R2 and R3 is independent. Consequence, Hal h, alkyl, optionally substituted aryl C1 - C6 6 - 10, optionally substituted,Alcarilo C1 - C2 - 4 heterociclilo optionally substituted, optionally replaced with Bridge 9, alcaheterociclilo c1-4 optionally replaced with a Bridge, heterociclilo C2 - 9 optionally replaced, or alcaheterociclilo c1-4 optionally substituted; each R4 and R7 is independently h, F, alkyl or alkoxy C1 C1 - 6 - 6; R5 is H, r5ac (NH) NH (CH2) R5 or r5anhc (S) NH (CH2) R5,Wherein R5 is an integer from 0 to 2, r5a is C1 - 6 optionally substituted alkyl, optionally substituted aryl c6-10 alcarilo C1, C2 - 4 - 9 heterociclilo optionally substituted, optionally substituted, optionally substituted alcaheterociclilo c1-4, tioalcoxi C1 - 6 optionally replaced, tioal Carilo c1-4 optionally replaced,Ariloilo optionally replaced tioalcaheterociclilo c1-4 or optionally substituted; and R6 H or r6ac (NH (CH2) or r6anhc R6 (S) NH (CH2) R6, wherein R6 is an integer from 0 to 2, r6a is C1 - 6 optionally substituted alkyl, optionally substituted aryl c6-10, alcarilo C1 4 - optionally replaced, I Terociclilo C2 - 9 optionally replaced, alcaheterociclilo c1-4 optionally replaced,Tioalcoxi C1 - 6 optionally replaced, tioalcarilo c1-4 ariloilo optionally substituted, optionally substituted, or tioalcaheterociclilo c1-4 optionally substituted; where one, but not both, R5 and R6 H.