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Design, Synthesis, Physical Properties and Indoleamine 2, 3-Dioxygenase 1 Inhibitory Activity of Substituted Indole Derivatives with N-H, N-Methoxymethyl, or N-Mehylthiomethyl Group toward Fragment-Based Drug Discovery

机译：设计，合成，物理性质和吲哚胺2,3双加氧酶1与N-H，N-甲氧基，或N- Mehylthiomethyl组朝向片段为基础的药物发现取代吲哚衍生物的抑制活性

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Mitsuhiro Arisawa; Kenta Hayami; Yuichi Kuboki; Katsumi Ohta; Bangzhong Lin; Megumi Fumimoto; Kazuto Nunomura; Jun-Ichi Haruta; Hiromichi Fujioka; Akira Asai; Kenichi Murai;
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1. Synthesis and inhibition study of monoamine oxidase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by 3,8-substituted 5H-indeno(1,2-c)pyridazin-5-one derivatives. [J] . Reniers J, Meinguet C, Moineaux L, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2011,第12期

机译：3,8-取代的5H-茚并（1,2-c）哒嗪-5-one衍生物对单胺氧化酶，吲哚胺2,3-二加氧酶和色氨酸2,3-二加氧酶的合成和抑制作用
2. Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A [J] . Dolu?i?E., LarrieuP., MeinguetC., Bioorganic and Medicinal Chemistry Letters . 2013,第1期

机译：海洋生物碱tsitsikammamine A衍生物的吲哚胺2,3-二加氧酶抑制活性
3. Palladium-Nanoparticle-Catalyzed 1,7-Palladium Migration Involving C?H Activation, Followed by Intramolecular Amination: Regioselective Synthesis of N1?Arylbenzotriazoles and an Evaluation of Their Inhibitory Activity toward Indoleamine 2,3-Dioxygenase [J] . Koji Takagi, Mohammad Al-Amin, Naoyuki Hoshiya, The Journal of Organic Chemistry . 2014,第13期

机译：钯-纳米粒子催化的涉及C？H活化的1,7-钯迁移，随后进行分子内胺化：N1？芳基苯并三唑的区域选择性合成及其对吲哚胺2,3-二加氧酶的抑制活性评估
4. Synthesis and Anti-HIV Integrase Inhibitory Activity of β-Diketo Derivatives of Mono-Substituted Calix arene [C] . Zaigang Luo, Xuemei Xu, Mingyang Zhang, International Conference on Chemical, Material and Metallurgical Engineering . 2013

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5. Part One. Synthesis of optically active tryptophan derivatives with potential activity as indoleamine 2,3-dioxygenase inhibitors: An approach via asymmetric catalytic hydrogenation. Part Two. Design, synthesis and pharmacology of selective ligands for alpha1-containing GABA(A)/benzodiazepine receptor subtypes: SAR studies of beta-carbolines at positions -3 and -6 and their corresponding bivalent ligands. Part Three. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. [D] . Yin, Wenyuan. 2007

机译：第一部分。具有吲哚胺2,3-二加氧酶抑制剂潜在活性的旋光色氨酸衍生物的合成：一种通过不对称催化氢化的方法。第二部分。含α1的GABA（A）/苯并二氮杂receptor受体亚型的选择性配体的设计，合成和药理作用：位于-3和-6位的β-咔啉及其相应的二价配体的SAR研究。第三部分。重要生物遗传中间体，（+）-聚神经氨酸和（+）-聚神经氨酸醛，以及16-表-维西辛和Macusine A的首次对映体全合成。
6. Inhibition Mechanism of Indoleamine 2 3-Dioxygenase 1 (IDO1) by Amidoxime Derivatives and Its Revelation in Drug Design: Comparative Molecular Dynamics Simulations [O] . Xinyu Liu, Yiwen Zhang, Huaichuan Duan, 2019

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7. Inhibition Mechanism of Indoleamine 2, 3-Dioxygenase 1 (IDO1) by Amidoxime Derivatives and Its Revelation in Drug Design: Comparative Molecular Dynamics Simulations [O] . Xinyu Liu, Yiwen Zhang, Huaichuan Duan, 2020

机译：吲哚胺2,3-二氧基酶1（IDO1）通过偕胺肟衍生物及其在药物设计中的启示抑制机制：对比分子动力学模拟

Design, Synthesis, Physical Properties and Indoleamine 2, 3-Dioxygenase 1 Inhibitory Activity of Substituted Indole Derivatives with N-H, N-Methoxymethyl, or N-Mehylthiomethyl Group toward Fragment-Based Drug Discovery

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