pyrazole derivatives as medicines for the treatment of acute or chronic neuronal degeneration

摘要

"PIRAZOL DERIVATIVES AS MEDICINAL PRODUCTS FOR THE TREATMENT OF ACUTE OR CHRONIC NEURONAL DEGENERENCES". The present invention relates to novel derivatives of formula (I), wherein A is, if present, a (C 1 -C 6) alkyl radical, a C 3 -C 6 alkenyl radical. 6 ~), a (C 3 -C 6 alkynyl) radical, a C 3 -C 7 cycloalkyl radical, a C 5 -C 7 cycloalkenyl radical, R ~ 1 ~ is a group NR 6 R 7, (C 4 -C 7 azacycloalkyl), C 5 -C 7 azacycloalkenyl, C 5 -C 9 azabicycloalkyl, C 1 -C 6 azabicycloalkyl ~ 5 ~ -C ~ 9 ~), AR¬ 1¬ is such that R ~ 1 ~ nitrogen and pyrazole nitrogen 1 are necessarily separated by at least two carbon atoms, R3 is a radical H, halogen, OH SH, NH2, ORc, SRc, SORa, SO2Ra, NHCHO, NRaRb, NHC (O) Ra, NHC (S) Ra, NHSO2Ra, R4 is an aryl or heteroaryl radical; R5 is a linear or branched H, halogen, CF3, CHF2, CH2F, (C 1 -C 6 alkyl) alkyl, C 3 -C 7 cycloalkyl radicals thereof, their racemic, enantiomers, diastereoisomers and mixtures thereof, their tautomers and their pharmaceutically acceptable salts.