PYRAZOLE DERIVATIVES AS MEDICINES FOR THE TREATMENT OF ACUTE OR CHRONIC NEURON DEGENERATIONS

摘要

The invention relates to novel derivatives of general formula (I), wherein A, if present, is an alkyl radical (C1-C6), an alkenyl radical (C3-C6), an alkynyl radical (C3-C6), a cycloalkyl radical (C3-C7), a cycloalkenyl radical (C5-C7), R1 is a NR6R7, azacycloalkyl (C4-C7), azacycloalkenyl (C5-C7) azabicycloalkyl (C5-C9) and azabicycloalkenyl (C5-C9) group; A-R1 is such that nitrogen of R1 et nitrogen 1 of pyrazole are indispensably separated by at lest two carbon atoms, R3 is an H, halogen, OH, SH, NH2, ORc, SRc, SORa, SO2Ra, NHCHO, NRaRb, NHC(O)Ra, NHC(S)Ra and NHSO2Ra radical; R4 is an aryl or heteroaryl radical; R5 is a H, halogen, CF3, CHF2, CH2F, linear or branched alkyl (C1-C6) and cycloalkyl (C3-C7) radical, the racemics, enantiomers and diastereoisomers thereof and the mixtures thereof, tautomers thereof and the pharmaceutically acceptable salts thereof.