A CCI-779 oral dosage form is provided in which, after oral administration to a subject, the CCI-779 has a whole blood peak concentration (Csubmax/sub) of 5.4 ?? 1.8 ng/mL and an area under the curve (AUC) of about 66 ?? about 22 ng-hr/ml and the sirolimus has a Csubmax/sub of 18.7 ?? 9.6 ng/mL and an AUC of about 600 ?? about 228 ng- hr/ml, for a 25 mg unit dose of CCI-779-Products containing these oral dosage forms, and methods of use thereof, are also described.
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机译：提供了一种CCI-779口服剂型，其中，在对受试者口服给药后，CCI-779的全血峰浓度（C max ）为5.4Ω·s。 1.8 ng / mL，曲线下面积（AUC）约为66 ??约22 ng-hr / ml，西罗莫司的C max 为18.7？ 9.6 ng / mL，AUC约为600 ??还描述了对于25 mg单位剂量的CCI-779约228 ng-hr / ml / mL，包含这些口服剂型的产品及其使用方法。
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