Monoisomerization 3.1.0 as a class of glycerol transport inhibitors

摘要

1. A single isomerized compound in which R1 is an isomer, such as pyridazole, thiazole, pyridine, pyridine, pyridine, pyrazole, etc.; R2, R3 and a are h or C1-C8 tar, optionally Oh, alcox C1-C8, nr7r8 or halogenated, q is - (CH2) n - (CH2) M-O -;N is an integer from 1 to 4; m is 2, 3 or 4; Z is arilo C6-C14, C1-C8 tar or cycloquilo c3-c8; R4 and R5 are h, halogen, C1-C8 tar, arilo C6-C14, etc.; and R6, - (CH2) or R6 -.-C (R6) 3 o-ch (R6) 2; or 1, 2 or 3; R6 is h, arilo C6-C14, C1-C10 asphalt, etc. - 1-1-1-1-1-6-1) O 1) O 1 [1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-x-6-methyl - [3 - (2) Amide of 2-dimethylacrylonitrile-4-fluorobenzene-1-methyl-1h-pyridan-4-carbohydrates,There are others A pharmaceutical composer was also mentioned These compounds are type 1 inhibitors of glycerol transport and can be used to treat the positive and negative symptoms of schizophrenia and other mental disorders.