Method and intermediate for preparing 7 - Antystrwjyn substituent 7-substituted antiestrogens especially Fwlfstrant fulvestrant

摘要

This standard specifies the preparation method of intermediate compounds - intermediate compounds - alkylhaloalkane, alkylhaloalkane, alkylalkenyl, cycloalkylalkyl, carboxylalkyl and alkylalkoxy compounds - R1. Carbonylalkyl, alkoxycarbonylalkyl, arylalkyl or arylalkylarylalkyl3. R2 is organic matter, as defined in the specification, including aromatization methods in X, N, R3, R2, R1 and R5, as shown in the figure, R4 or R4 One or more steps, if necessary or desirable, may be carried out.The following two Figures: (1) Remove any hydroxy protecting group R groups, (2) convert an introductory group R4 to an R4 group, or where R4 denotes an R4 group, and convert them into a different group. The resulting compounds are useful intermediates, for example, in Prepare a fulvestrant. This invention also protects new intermediate materials.