7-SUBSTITUTED FLUORO-2- ACETYL-2-a, 4-a, 5, 12-TETRAOXY-1,2,3,4-TETRAHYDRO-6,11-NAPHTHACENEDIONES AS INTERMEDIATES FOR PREPARING ANTHRACYCLINE DERIVATIVES HAVING ANTITUMOR AND ANTIVIRAL ACTIVITY, ANTHRACYCLINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, NAPHTHACENEDIONES AS INTERMEDIATES FOR PREPARING 7-SUBSTITUTED FLUORO-2-b-ACETYL-2-a, 4-a, 5, 12-TETRAOXY-1, 2, 3, 4-TETRAHYDRO-6, 11-NAPHTACENEDIONE DERIVATIVES

摘要

FIELD: medicine. SUBSTANCE: the product: naphthacenediones of formulas 1, 2 and 3; anthracycline derivatives of formula 4. Reagent 1: 1,4-dimethoxy-2,3-bis)bromomethyl) anthraquinone. Reagent 2: 3-butin-2-one. Reagent 3: a peroxide compound. Reagent 4: nucleaophilic fluorine. Reagent 5: hydroxyl-containing phenyl. Reagent 6: naphthacenedione. Reagent 7: bromine. Reaction conditions: cyclization, epoxidation demethylation, bromination. The structure of the compounds of formulas 1, 2, 3 and 4. EFFECT: improved properties of the resulting compounds. 5 cl, 6 tbl