derivatives of n - (3 - ylamide pyrrolidine inhibitors of reabsorption as serotonin and noradrenaline

摘要

Compounds of formula () and their pharmaceutically and / or veterinary acceptable derivatives. In the form,R1 stands for H, C1 to C6 alkyl, - c() y, C3 to C8 cycloalkyl, aryl, het, (C1 to C4 alkyl) or het ("C1 to C4 alkyl"),Among them, cycloalkanes, aryls or hetes are optionally substituted, and at least one of the substituents is independently selected among C1-C8 alkyl substituents, C1-C8 alkyl substituents, oh, halogenated, CF3, ocf3, ScF3 and hydroxyalkyl among c1-c6alkyl substituents.("alkoxy en C1-C4" ("alkyle en C1-C6") and ("alkyle en C1-C4");R2 represents an aryl or heteroaryl group, each selectively substituting at least one substituent, an alkyl substituent from C1 to C8, an alkyloxy group from C1 to C8, oh, halogenated, C3, ocf3, ScF3, a hydroxyalkyl group from C1 to C6, ("alkyl group from C1 to C4") ("alkyl group from C1 to C6") and ("alkyl group from C1 to C4") ("alkyl group from C1 to C4");R3 is an alkyl group of C1 to C6, a cycloalkyl group of C3 to C8 ("a cycloalkyl group of C3 to C8") ("an alkyl group of C1 to C6"),Aryl, het, aryl (- C1-C4 alkyl) or het (- C1-C4 alkyl),Among them, cycloalkyl, aryl or heptyl groups are selectively substituted, at least one of which is independently selected in c1-c6alkyl substituent, c1-c6alkyloxy, oh, halogenation, C3, ocf3, ScF3, hydroxyalkyl, c1-c6alkyl, (c1-c6alkyl) and () C1-C4 alkyl () C1-C4 alkyl ();X stands for s or O;Y stands for H, c1-c6alkyl, aryl, het, aryl ("C1-C4 alkyl") or, het ("C1-C4 alkyl");N equals 1 or 2;But if n equals 1, m equals 0 or 1, and if n equals 2, m equals 0, orIf M equals 0, * indicates the operating center. The compound of the invention has activity as a serotonin and norepinephrine reuptake inhibitor and can be used in various therapeutic fields, such as urinary incontinence.