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USE OF HUMAN OATP-C POLYMORPHISMS THAT HAVE AN EFFECT ON THE PHARMACOKINETICS OF STATIN IN STATIN-THERAPY
USE OF HUMAN OATP-C POLYMORPHISMS THAT HAVE AN EFFECT ON THE PHARMACOKINETICS OF STATIN IN STATIN-THERAPY
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机译:在人他汀治疗中对人他汀药代动力学有影响的人类OATP-C多态性的使用
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摘要
This invention relates to use of polymorphisms in human OATP-C in statin therapy because they are associated with an effect on statin pharmacokinetics (PK) in humans, especially rosuvastatin pharmacokinetics. The invention also relates to the use of OATP-C polymorphisms in predicting the efficacy and safety of statins, whose uptake in to the liver is mediated by OATP-C, especially rosuvastatin.
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