DERIVATIVES OF PIPERIDINE AND ITS USE AS MODULATORS OF THE ACTIVITY OF CHEMIOKINS (ESPECIALLY OF CCR3).

摘要

. A compound of formula (I): T is C (O) or S (O) 2; W is CH2, (CH2) 2, CH (CH3), CH (CH3) O or cyclopropyl; X is O; m is 0 or 1; R1 is phenyl substituted with one or more of fluorine, chlorine, C1-4 alkyl or C1-4 alkoxy, R2 is phenyl or heterocyclyl, any of which is optionally substituted with: halo, hydroxy, nitro, cyano, oxo, amino, C1-4 alkyl (itself optionally substituted with S (O) 2 (C1-4 alkyl), S (O) 2phenyl), C1-4 alkoxy, S (O) kR24 (where k is 0, 1 or 2 ); and R24 is C 1-4 alkyl, C 1-4 hydroxyalkyl, C 3-7 cycloalkyl (C 1-4 alkyl) (such as a cyclopropylmethyl) or phenyl), C 1-4 haloalkylthio, C (O) NH 2, NHS (O) 2 (C1-4 alkyl), S (O) 2NH2, S (O) 2NH (C1-4 alkyl) or S (O) 2N (C1-4 alkyl) 2; Heterocyclyl is furyl, thienyl, pyrrolyl, 2,5-dihydropyrrolyl, thiazolyl, pyrazolyl, oxazolyl, isoxazolyl, imidazolyl, piperidinyl, morpholinyl, pyridinyl, pyrimidinyl, indolyl, 2, 3- dihydroindolyl, benzo [b] furyl, benz [b] furyl, benz thienyl, 2, 3- dihydrobenz [b] thienyl, indazolyl, benzimidazolyl, benztriazolyl, benzoxazolyl, benzthiazolyl, 2, 3-dihydrobenzthiazolyl, 1, 2, 3- benzothiadiazolyl, an imidazopyridinyl, thieno [3, 2-6] pyrid -yl, 1, 2, 3-benzoxadiazolyl, 2, 1, 3-benzothiadiazolyl, benzofurazano, quinoxalinyl, dihydro-1-benzopyryloxy, 3, 4-dihydro-1H-2, 1- benzothiazinyl, a pyrazolopyridine, a purine, quinolinyl , isoquinolinyl, naphthyridinyl, benzothiazinyl, benzo [d] imidazo [2, 1- b] thiazol-2-yl or dibenzothiophenyl; or an N-oxide thereof, or an S-oxide or S-dioxide thereof; or 1, 2, 4-oxadiazolyl, 1, 2, 3- triazolyl, tetrazolyl, pyridazinyl, thieno [2,3-b] pyridinyl, pyrazolo [5, 1-c] [1, 2, 4] triazinyl, purinyl, pyrazolo [1, 5- a] pyrimidinyl, thieno [2,3-c] pyrazolyl or phthalazinyl; or an N-oxide thereof; or a pharmaceutically acceptable salt thereof; or a solvate of it.