NON-THROMBOGENIC AND ANTI-THROMBOGENIC POLYMERS

摘要

Polymers having non-thrombogenic properties can be prepared by copolymerisingmonomers of at least three classes selected from (a)monomers having sulphate groups, (b) monomers having sulphonate groups, (c)monomers having sulphamate groups, and (d) monomershaving polyoxyalkylene ether groups, (e) monomers having zwitterionic groups.The monomers can additionally be provided withanti-thrombogenic properties by including an additional comonomer having apendant heparin (or hirudin, warfarin or hyaluronic acid) group.The polymers can be used as coating materials for medical devices, such astubing or connectors, in order to provide them withnon-thrombogenic, and optionally anti-thrombogenic, properties.