HUMAN GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR PROMOTERS, VECTORS CONTAINING SAME, AND METHODS OF SCREENING COMPOUNDS THEREWITH

摘要

The distal and proximal promoters for the human glial cell line-derivedneurotrophic factor (GDNF) gene are provided. In addition,constructs comprising a human GDNF promoter and a reporter gene, a vectorcomprising the construct and a host cell comprising thevector are provided, as is a method for screening compounds capable ofmodulating the expression of GDNF by stimulating GDNFpromoter-directed transcription.