N-DIHYDROXYALKYL-SUBSTITUTED 2-OXO-IMIDAZOLE DERIVATIVES

摘要

It is intended to provide a compound represented by the formula (I) (I)(wherein R represents an alkyl group having 1 to 6 carbon atoms substitutedwith 2 hydroxyl groups, Cy represents a bicyclic or tricyclic aliphaticcarbocyclic group having 6 to 10 carbon atoms which may have a substituent insome cases). The compound acts as a nociceptin receptor antagonist and isuseful as, for example, a narcotic analgesic resistance reversal agent; areversal agent for narcotic analgesic dependency or withdrawal syndrome; ananalgesic action enhancing agent; an anti-obesity agent or an appetite controlagent; an improving agent or preventive agent for decline in learning andmemory abilities or dementia symptom; an improving agent for cognitivefunction in the developmental stage; a therapeutic agent for schizophrenia; atherapeutic agent for regressive neurodegenerative disease; an antidepressantagent or an emotion control agent; a therapeutic agent or preventive agent fordiabetes insipidus; a therapeutic agent or preventive agent for polyuria; atherapeutic agent for hypopiesis and the like.