NOVEL MICROORGANISM CATALYZING REGIOSELECTIVE HYDROXYLATION OF 6 CYCLIC COMPOUND CONTAINING NITROGEN AND METHOD FOR PRODUCING HYDROXYLATED 6 CYCLIC COMPOUND CONTAINING NITROGEN USING THE SAME

摘要

The present invention relates to a novel microorganism of the genus Alcaligenes, which catalyzes the regioselective hydroxylation of nitrogen-containing six-membered cyclic compounds, including nicotinic acid, pyrazine carboxylic acid and picolinic acid, as well as a method for producing a nitrogen-containing hydroxylated six-membered cyclic compound using said microorganism. The novel microorganism Alcaligenes faecalis LGNA2 according to the present invention is effective in catalyzing the regioselective hydroxylation of nitrogen-containing six-membered cyclic compounds such as nicotinic acid, pyrazine carboxylic acid and picolinic acid and has a high efficiency for converting the six-membered cyclic compounds into other compounds. Accordingly, it can be widely used in synthesizing nicotine and pyrazine derivatives in large amounts.