NOVEL MICROORGANISM CATALYZING REGIOSELECTIVE HYDROXYLATION OF 6 CYCLIC COMPOUND CONTAINING NITROGEN AND METHOD FOR PRODUCING HYDROXYLATED 6 CYCLIC COMPOUND CONTAINING NITROGEN USING THE SAME

摘要

A novel Alcaligenes faecalis LGNA2 is provided to be able to efficiently convert nicotinic acid into 6-hydroxy nicotinic acid with high yield through regioselective hydroxylation. To prepare a compound represented by the formula(2), a compound represented by the formula(1) is regioselectively hydroxylated by using a novel Alcaligenes microorganism such as Alcaligenes faecalis LGNA2. In the formula(1), R is C or N, and each R1 and R2 is independently H, carboxyl, carbamoyl, cyano, formyl, C1-5 hydroxy alkyl, C2-6 alkoxy carbonyl, carboxyl vinyl, carboxy methyl or oxime, provided that at least one of R1 and R2 is carboxyl.