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EXPRESSION AND SECRETION VECTOR FOR HUMAN INTERFERON ALPHA AND PROCESS FOR PRODUCING HUMAN INTERFERON ALPHA BY EMPLOYING SAME
EXPRESSION AND SECRETION VECTOR FOR HUMAN INTERFERON ALPHA AND PROCESS FOR PRODUCING HUMAN INTERFERON ALPHA BY EMPLOYING SAME
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机译:人干扰素α的表达和分泌载体及采用相同方法生产人干扰素的方法
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摘要
Disclosed in this invention are: an expression vector for the secretive production of human interferon alpha (hIFNα) comprising a polynucleotide encoding a modified E. coli thermostable enterotoxin II signal sequence and a polynucleotide encoding hIFNα) ligated to the 3"-end thereof; a microorganism transformed with the expression vector; and a process for secretively producing human interferon by culturing the microorganism, said process being capable of secreting a soluble form of active hIFNα), which does not contain an additional methionine residue at its N-terminal, into the periplasm of an E. coli cell.
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