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CAPTURE, CONCENTRATION AND QUANTITATION OF ABNORMAL PRION PROTEIN FROM BIOLOGICAL FLUIDS USING DEPTH FILTRATION
CAPTURE, CONCENTRATION AND QUANTITATION OF ABNORMAL PRION PROTEIN FROM BIOLOGICAL FLUIDS USING DEPTH FILTRATION
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机译:深度过滤法从生物流体中捕获,浓缩和定量异常PR蛋白
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摘要
Methods for producing biological solutions such as immunoglobulins and in particular anti-D immunoglobulin substantially free of abnormal prion protein resulting therefrom. Specifically provided are methods for aggregation of prions and depth filtration of the biological solution to capture and remove abnormal and if desired, normal prion protein. The prion protein may then be eluted from the depth filter and filter washes and concentrated sufficient for detection at limits currently required by available assays.
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