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DRUG RESISTANCE TO PLANT ALKALOIDS BASED UPON MYD88 STATUS IN A CELL AND METHODS OF INHIBITING SIGNALING THROUGH THE TLR-4:MYD88 PATHWAY
DRUG RESISTANCE TO PLANT ALKALOIDS BASED UPON MYD88 STATUS IN A CELL AND METHODS OF INHIBITING SIGNALING THROUGH THE TLR-4:MYD88 PATHWAY
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机译:基于细胞中MYD88状态对植物碱的药物抗性及通过TLR-4:MYD88途径抑制信号传递的方法
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摘要
Described herein is a cellular marker, MyD88, useful for assessing an individual's (patient's) sensitivity (or resistance) to chemotherapy, particularly sensitivity (or resistance) to chemotherapeutic drugs, such as plant alkaloids (e.g., a taxane, such as paclitaxel or docetaxel). As described herein, Applicants provide a method by which it is possible to determine whether an individual (cancer cells in an individual) is sensitive to chemotherapy with plant alkaloids (e.g., a taxane, such as paclitaxel or docetaxel). Early identification of chemoresistance in patients with cancer is of utmost importance, particularly since it makes it possible to provide the most appropriate therapy.
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