METHOD FOR THE TREATMENT OF TUMORS BY ANTIANGIOGENIC SUBSTANCES

摘要

This invention provides a compound comprising a recombinant nucleic acid encoding an antiangiogenic protein inserted within a viral nucleic acid, wherein the recombinant nucleic acid can be packaged in a virus particle and wherein expression of the recombinant nucleic acid encoding the antiangiogenic protein results in production of the antiangiogenic protein. The present invention also provides a method of delivering an antiangiogenic protein to a cell, delivering an antiangiogenic protein to a subject, and treating a tumor in a subject comprising administering a virus comprising a recombinant nucleic acid encoding an antiangiogenic protein inserted within the viral nucleic acid, wherein the recombinant nucleic acid can be packaged in a virus particle, and wherein expression of the recombinant nucleic acid encoding the antiangiogenic protein results in production of the antiangiogenic protein, thereby delivering the antiangiogenic protein to the cell.