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KRISTALLSTRUKTUR DER 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHAT-SYNTHASE
KRISTALLSTRUKTUR DER 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHAT-SYNTHASE
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机译:2C-甲基-D-赤藓醇-2,4-环磷酸酯合酶的晶体结构
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摘要
This invention discloses the crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and crystal structures of said synthase with 4-diphosphocytidyl-2C-methyl-D-erythritol, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate, cytidine monophosphate, cytidine diphosphate, cytidine and a combination of cytidine monophosphate and 2C-methyl-D-erythritol 2,4-cyclodiphosphate; with or without zinc. Further, computer-aided methods of identifying inhibitors of said synthase and inhibitors are provided.
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