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L - isoleucine extruding bacterium and method for the production of l - isoleucine by fermentation
L - isoleucine extruding bacterium and method for the production of l - isoleucine by fermentation
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机译:L-异亮氨酸挤压细菌及通过发酵生产l-异亮氨酸的方法
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摘要
An L-isoleucine-producing bacterium belonging to the genus Escherichia which carries a thrABC operon which comprises a thrA gene coding for aspartokinase I-homoserine dehydrogenase I substantially released from the inhibition by L-threonine and an ilvGMEDA operon which comprises an ilvA gene coding for threonine deaminase substantially released from the inhibition by L-isoleucine and whose region required for attenuation is removed; and an L-isoleucine-producing bacterium belonging to the genus Escherichia carrying the thrABC operon, an lysC gene coding for aspartokinase III substantially released from the inhibition by L-lysine, and the ilvGMEDA operon. The bacteria permit biosynthesis of a sufficient amount of L-isoleucine.
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