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NOVEL PROTECTING GROUPS AND USE THEREOF IN AN IMPROVED PROCESS FOR OLIGONUCLEOTIDE SYNTHESIS
NOVEL PROTECTING GROUPS AND USE THEREOF IN AN IMPROVED PROCESS FOR OLIGONUCLEOTIDE SYNTHESIS
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机译:新型保护基团及其在寡核苷酸合成的改进方法中的应用
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摘要
PROBLEM TO BE SOLVED: To facilitate the synthesis of phosphoramidite oligonucleotide.;SOLUTION: The phosphoramidite oligonucleotide synthesis is facilitated by the use of 5' silyl protecting groups having high reactivity with iodine. RNA synthesis is improved by the use of 2' orthoester protecting groups. Reactions are conducted on a solid phase support and acidic deprotection conditions are avoided, as is the necessity of oxidizing the phosphite linkage between each coupling reaction.;COPYRIGHT: (C)2008,JPO&INPIT
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