METHOD FOR PURIFYING EDARAVONE AND HIGHLY PURE EDARAVONE

摘要

PROBLEM TO BE SOLVED: To provide a method for profitably obtaining highly pure edaravone capable of being supplied as a stock medicine for injections, and to provide the highly pure edaravone of its resulting product.;SOLUTION: This method for purifying the edaravone is characterized by recrystallizing crude edaravone from an organic solvent in the presence of a reducing agent. The highly pure edaravone, wherein the purity of the edaravone is ≥99.9%, and the highly pure edaravone, wherein the edaravone substantially does not contain the oxidative polymer of the edaravone as an impurity or has its content of ≤0.1% are disclosed.;COPYRIGHT: (C)2008,JPO&INPIT