HIGHLY PURE BLOOD COAGULATION FACTOR IX PREPARATION AND METHOD OF PURIFYING THE SAME

摘要

A method of purifying blood coagulation factor IX characterized by comprising eliminating a blood coagulation factor IX activator from a fraction containing blood coagulation factor IX and thus inhibiting the formation of activated blood coagulation factor IX; and a blood coagulation factor IX preparation obtained by this method which contains little FIXa and has a high safety. The blood coagulation factor IX activator as described above is mannose-binding lectin-associated serine protease-1 (MASP-1). It is preferable to eliminate the blood coagulation factor IX activator by hydrophobic chromatography.