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Intracellular delivery system of bioactive agents based on polymeric drug carriers containing amphiphilic block copolymers and polylactic acid derivatives
Intracellular delivery system of bioactive agents based on polymeric drug carriers containing amphiphilic block copolymers and polylactic acid derivatives
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机译:基于含有两亲嵌段共聚物和聚乳酸衍生物的聚合物载体的生物活性剂的细胞内递送系统
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摘要
Delivery system for bioactive agents on the basis of a polymeric drug carrier formed from compositions comprising an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block having a terminal hydroxyl group substituted with a tocopherol or cholesterol group, and a polylactic acide derivative wherein one end of the polylactic acid is covalently bound to at least one carboxyl group. The carboxyl group of the polylactic acid derivative may be fixed with a di- or trivalent metal ion, which is obtained by adding the di- or trivalent metal ion to the polymeric composition.
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