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Substituted purinyl derivatives with immunomodulatory and chemoprotective activities and their use alone or in combination with medium chain fatty acids or glycerides
Substituted purinyl derivatives with immunomodulatory and chemoprotective activities and their use alone or in combination with medium chain fatty acids or glycerides
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机译:具有免疫调节和化学保护活性的取代嘌呤衍生物及其单独使用或与中链脂肪酸或甘油酯组合使用
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摘要
The present invention describes new biological activities of immunomodulating 6-substituted purinyl compounds which make them particularly useful during the treatment of cancer. Collectively, these new biological activities make these purinyl compounds useful chemoprotective agents for the treatment of myelosuppression which is associated with cancer chemotherapy and/or radiotherapy. This chemoprotective activity is in addition to the immunomodulating and subsequent anticancer activity displayed by these compounds. The chemoprotective usefulness of these compounds is further enhanced by the use of medium-chain fatty acids or salts or triglycerides or mono- or diglycerides in combination with the 6-substituted purinyl compounds of this invention.
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