Is dissolved in a solvent opium, heat the opium solution dissolved, cooling the opium solution dissolved, combined with a weak acid of the first one, the filtrate by filtration opium solution prepared by dissolving at least the pH of opium solution of recovered; involves then separation and purification of alkaloids at least one from the filtrate, and extracting from the opium alkaloid at least one. Preferably, after acid combined in the first one, which comprises the further step of cooling the solution opium least the pH of the solution opium dissolved. Method for separation and purification of alkaloids preferred one includes the use of preparative liquid chromatography, at least in the filtrate, however, filtration and solvent extraction can also be used.
展开▼