Peptide or protein having binding ability to LipidA and LPS, DNA encoding the peptide or protein, LPS adsorbent or LPS toxicity neutralizing agent using the peptide or protein

摘要

The present invention provides a novel peptide or protein capable of binding to Lipid A and LPS, which is highly safe and inexpensive, and a DNA encoding the peptide or protein, and uses the peptide or protein. Provided LPS adsorbent and LPS toxicity neutralizer. Screening is performed by the phage display method using Lipid A or LPS as a target substance, and the amino acid sequence of a peptide having binding ability to Lipid A and LPS and the DNA encoding the amino acid sequence are identified. Modification, amino acid residue substitution, insertion and / or amino acid sequence shown in any one of SEQ ID NOs: 1 to 6 thus obtained, or in the amino acid sequence as long as the binding to Lipid A is not impaired A peptide having a deleted amino acid sequence can be easily chemically synthesized. For example, an LPS adsorbent can be obtained by immobilizing the peptide on a carrier. An LPS toxicity neutralizing agent can be obtained by containing the peptide as an active ingredient.