首页>
外国专利>
Astrocyte Elevated Gene-1 And Its Promoter In Treatments For Neurotoxicity And Malignancy
Astrocyte Elevated Gene-1 And Its Promoter In Treatments For Neurotoxicity And Malignancy
展开▼
机译:星形胶质细胞升高的基因-1及其启动子治疗神经毒性和恶性肿瘤
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention is based, at least in part, on the discovery that Astrocyte Elevated Gene-1 (‘AEG-1’) expression (i) suppresses the Excitatory Amino Acid Transporter-2 (‘EAAT-2’) promoter, thereby inhibiting glutamate transport; (ii) supports anchorage independent colony formation of cells, in which it is synergistic with the RAS oncogene; and (iii) is increased in a number of different malignancies. The invention, in various embodiments, provides for methods of treatment of malignancies and neurodegenerative disorders using inhibitors of AEG-1 activity, and provides for screening assays for identifying other compounds that have therapeutic benefit.
展开▼