首页>
中文期刊>
《当代医学科学(英文)》
>RASSF2A Promoter Methylation in Hepatitis B Virus-related Hepatocellular Carcinogenesis and Its Correlation with Elevated Serum α-Fetoprotein Level
RASSF2A Promoter Methylation in Hepatitis B Virus-related Hepatocellular Carcinogenesis and Its Correlation with Elevated Serum α-Fetoprotein Level
Loss of the RASSF2A expression induced by methylation-mediated silencing has been reported in several human cancers, but the methylation status of RASSF2A in hepatocellular carci-noma (HCC) is rarely studied so far. In this study, we investigated the RASSF2A expression and its methylation status in a cohort of 45 hepatitis B virus-associated HCC tissues and their adjacent non-carcinoma tissues by using RT-PCR and MS-PCR. Promoter methylation of RASSF2A was found in 31 (68.9%) out of 45 HCC tissues and 12 (40%) out of 30 adjacent normal tissues, respec-tively (P<0.05). The methylation status of PASSF2A was closely associated with the loss of RASSF2A expression and elevated serum α-fetoprotein level, but not significantly with clinical stage, hepatic fibrosis and K-ras mutation. It was concluded that aberrant methylation of the RASSF2A gene with the subsequent loss of RASSF2A expression plays an important role in the pathogenesis of HCC.
展开▼
机译:Untersuchung zur konzentrationsentwicklung in der ernahrungsindustirie in Deutschland。 Ernährungsindustrie(ohneGetränkeindustrie)insgesamt(N.I.C.E。20B)。Herstellung von Fleischkonserven(N.I.C.E.201)。 Herstellung von Obst-undGemüsekonserven(N.I.C.E.203)。Herstellung von Fischkonserven(N.I.C.E.204)=关于德国食品工业集中发展的研究。食品工业(不包括饮料)总计(NICE 20B)。罐头肉的生产(N.I.C.E 201)。水果和蔬菜蜜饯的制造(N.I.C.E.203)。鱼类罐头的制造(N.I.C.E. 204)