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Prevention of damage in hippocampus of fetus/newborn infant due to maternal gestational hypertension
Prevention of damage in hippocampus of fetus/newborn infant due to maternal gestational hypertension
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机译:预防母体妊娠高血压对胎儿/新生儿海马的损害
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摘要
The present invention provides a method for preventing or ameliorating neural damage in a mammalian fetus or a newborn infant, which is caused by maternal gestational hypertension (GH). The method includes orally administering germination activated sporoderm-broken Ganoderma lucidum spores (“GLSs”) to a pregnant mammal having GH. The neural damage includes a decrease in hippocampal cell proliferation and neuron number. The present invention further provides a method for preventing or ameliorating the increased expression of hippocampal hypoxia inducible factor (HIF-1a) and vascular endothelial growth factor (VEGF) in a mammalian embryo caused by maternal GH.
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