Vaccine Composition Against Rhodococcus Equi

摘要

The invention concerns a method for preparing a soluble antigenic extract from Rhodococcus equi, comprising a step of solubilizing membranes of said bacteria by contacting said bacteria with an extraction solution containing a nonionic detergent of sorbitan polyethylene fatty acid ester type. The invention also concerns a soluble antigenic extract obtainable by said preparation method, said extract comprising membrane antigens of Rhodococcus equi dissolved in the extraction solution. Finally the invention concerns a composition comprising the soluble antigenic extract as medicine, comprising preferably a nanoparticulate or oil-in-water emulsion type adjuvant, and the use of the soluble antigenic extract for preparing a pharmaceutical composition for preventing or treating a Rhodococcus equi-induced infection in an animal.