VACCINE COMPOSITION AGAINST RHODOCOCCUS EQUI

摘要

A method for preparing a soluble antigenic extract from Rhodococcus equi is disclosed. The method includes a step of solubilizing membranes of said bacteria by contacting said bacteria with an extraction solution containing a nonionic detergent of sorbitan polyethylene fatty acid ester type. Also disclosed is a soluble antigenic extract obtainable by said preparation method, said extract including membrane antigens of Rhodococcus equi dissolved in the extraction solution. Finally, a composition including the soluble antigenic extract as a medicine is disclosed, including preferably a nanoparticulate or oil-in-water emulsion type adjuvant, and the use of the soluble antigenic extract for preparing a pharmaceutical composition for preventing or treating a Rhodococcus equi-induced infection in an animal.