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Rationally designed and chemically synthesized promoter for genetic vaccine and gene therapy
Rationally designed and chemically synthesized promoter for genetic vaccine and gene therapy
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机译:合理设计和化学合成的启动子,用于基因疫苗和基因治疗
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摘要
The present invention relates to chemically synthesized promoters that circumvent the disadvantages of the universal CMV promoter/enhancer elements. The promoter may be used in a variety of applications, particularly in genetic immunization. The chemically synthesized promoter overcomes the common problems of the CMV promoter element such as: low transgene expression levels, transient expression, and the large amount of plasmid DNA needed for intramuscular injection in subjects.
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