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Method for producing genetically-modified cells with rationally-designed meganucleases with altered sequence specificity
Method for producing genetically-modified cells with rationally-designed meganucleases with altered sequence specificity
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机译:用合理设计的,具有改变的序列特异性的大范围核酸酶生产转基因细胞的方法
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摘要
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
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