Substituted benzimidazoles and Methods for use as inhibitors of kinases associated with tumorigenesis

摘要

In some embodiments, the compounds and compositions are effective to inhibit the activity of at least a serine / Threonine Kinase and tyrosine kinase receptors.The compounds and compositions may be used alone or in combination with at least one additional agent for treating a disorder mediated by a serine / Threonine Kinase and tyrosine kinase Receptors, such as cancer.Claim 1: wherein is a compound of formula (1), wherein each R1 is selected independently between Hydroxy alkyl, Halo, C1 - 6, 6 - (alkyl alkoxy C1, C1 - 6) sulfanilo (C1 - sulfonyl alkyl, cycloalkyl, 6) heterocicloalquilo phenyl heteroaryl, and R2 is alqui; The C1 - 6 or Halo (alkyl C1 - 6); R3 are each independently selected from alkyl, Halo, C1 - 6Alkoxy and C1 - 6; each R4 is selected independently between Hydroxy alkyl, alkoxy C1 C1 - 6 - 6, Halo (alkoxy, carboxyl, carbonyl, aminocarbonilo C1 - 6), alquilaminocarbonilo C1 - 6, carbonitrilo, cycloalkyl, heterocicloalquilo, heterocicloalquilcarbonilo, phenyl, and heteroaryl; where R1, r 2 R3And R4 may be optionally substituted with one or more substituents selected independently between Hydroxy alkyl, Halo, Halo (C1 - 6, 6 - alkoxy alkyl C1, C1) and Halo (- 6, 6 - alkoxy C1); a is 1, 2, 3, 4, or 5; b is 0, 1, 2, or 3; and C is 1 or 2; or a stereoisomer, polymorphic, and tautomero, Ster, metabolite, or a Salt or prodrug thereof acceptable for pharmaceutical use of the compoundTautomero, stereoisomer, polymorphic, metabolite, Ester or prodrug.