Salts of duloxetine, Enhanced Synthesis of the compound and Pharmaceutical formulation

摘要

Salts and improved process to prepare Duloxetine Duloxetine Hydrochloride. More particularly, This relates to the preparation of Duloxetine Hydrochloride by a process that provides a maximum yield of the desired product with a minimum amount of unwanted side products. These compounds are useful in the treatment of Depressive Disorders.Claim 1 is characterized in that: a Compound, 4 - (3 - metilamin - 1 - thiophen-2-yl - propyl) - naftalen - 1 - ol (u00f4compuesto2u00f6) of formula (1) and salts thereof, where the hydrochloride Salt of the compound 2 is characterized by 1H NMR (400 MHz, DMSO) with characteristic Peaks 10.17 (1H, S) - 8.8 9.1 (2H, s width, 8,16 (1H), (d), 8 (7.48 (1H, 1h, (d), (T), 7.42 7.33 (1H, 1h, T), (d), 7.28 (1H, (d), 704 (6.92 (1H, 1h, (d), T, 6.89 (1H), D (1H), 5.09, T, (char), 2.85 m (2H, 5H, and 2.56 m approximately).