immobilized markers and conformational altered prion detection methods

摘要

IMMOBILIZED MARKERS AND CONFORMALLY CHANGED PRION DETECTION METHODS The present invention provides methods of making immobilized markers that are specific for prion proteins, methods of using such markers to bind, detect, and remove prion proteins from samples, and kits for developing the invention. . The invention discloses immobilized markers that are sealed in a particular, predetermined configuration and that retain their activity and specificity even when exposed to conditions that could typically alter their activity and specificity.