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opioid dosage forms having steady-state mean and auc proportional to dose and single dose cmax lower than dose proportional
opioid dosage forms having steady-state mean and auc proportional to dose and single dose cmax lower than dose proportional
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机译:阿片类药物剂型的稳态平均值和auc与剂量成正比,单剂量cmax低于剂量成比例
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摘要
"OPOID PHARMACEUTICAL FORM HAVING C-MEDIA AND AUC IN STABLE PROPORTIONAL TO DOSE AND C-MAX DOSE OF SINGLE LESS THAN PROPORTIONAL TO DOSE". The present invention relates to various pharmaceutical forms comprising a first pharmaceutical form and a second pharmaceutical form each comprising a therapeutic agent, for example an opioid; characterized by the fact that the dose strength of the second pharmaceutical form is greater than the dose strength of the first pharmaceutical form; and where steady-state mean and steady-state AUC of the first and second pharmaceutical forms are proportional to the single-dose dose and the max-dose ac-max ~ of the second pharmaceutical form is below the minimum dose proportionality level with respect to the first form. Pharmaceutical The present invention also relates to methods of administering such dosage forms to a patient, as well as kits comprising such dosage forms and instructions for administering the dosage forms to a patient. The inventors believe that the pharmaceutical forms and methods of the present invention will result in greater patient safety and acceptance.
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