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Dose proportionality and pharmacokinetics of carvedilol sustained-release formulation: a single dose-ascending 10-sequence incomplete block study

机译：卡维地洛缓释制剂的剂量比例和药代动力学：单剂量递增10序列不完全阻断研究

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摘要

BackgroundCarvedilol is a third-generation β-blocker indicated for congestive heart failure and high blood pressure. The aim of this study was to investigate the dose proportionality of the carvedilol sustained-release (SR) formulation in healthy male subjects.

机译：背景卡维地洛是第三代β受体阻滞剂，适用于充血性心力衰竭和高血压。这项研究的目的是调查在健康男性受试者中卡维地洛缓释（SR）制剂的剂量比例。

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期刊名称 Drug Design Development and Therapy
作者
Yo Han Kim; Hee Youn Choi; Yook-Hwan Noh; Shi Hyang Lee; Hyeong-Seok Lim; Chin Kim; Kyun-Seop Bae;
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作者单位

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年(卷),期 2015(9),-1
年度 2015
页码 2911–2918
总页数 8
原文格式 PDF
正文语种
中图分类药学 ; 药物化学 ;
关键词
dose linearity carvedilol sustained release healthy subjects;

机译：剂量线性;卡维地洛;持续释放;健康受试者;

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专利

1. Dose proportionality and pharmacokinetics of?carvedilol sustained-release formulation: a?single dose-ascending 10-sequence incomplete block study [J] . Yo Han Kim, Hee Youn Choi, Yook-Hwan Noh, Drug Design, Development and Therapy . 2015 ,第5期

机译：卡维地洛缓释制剂的剂量比例和药代动力学：单剂量递增10序列不完全阻断研究
2. Bioequivalence and pharmacokinetic evaluation of two tablet formulations of carvedilol 25-mg: A single-dose, randomized-sequence, open-label, two-way crossover study in healthy Chinese male volunteers [J] . CentralLaboratoryShanghaiXuhuiCentralHospital Drug research . 2013 ,第2期

机译：两种片剂配方的生物等效和药代动力学评价25-mg：一种单剂量，随机序列，开放标签，健康中国男性志愿者的双向交叉研究
3. Tolerability and dose proportional pharmacokinetics of pasireotide administered as a single dose or two divided doses in healthy male volunteers: A single-center, open-label, ascending-dose study [J] . PetersennS., HuK., MaldonadoM., Clinical therapeutics . 2012 ,第3期

机译：在健康男性志愿者中以单剂量或两剂量分剂量服用帕雷肽的耐受性和剂量比例药代动力学：单中心，开放标签，递增剂量研究
4. Dose Proportional Pharmacokinetics of a Methylphenidate Extended-Release Capsule Formulation [C] . Controlled Release Society annual meeting . 2004

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5. Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine, bioavailability and bioequivalence of verapamil HCL controlled release formulations, pharmacokinetics of terbinafine after single oral doses in raptors. [D] . Fahmy, Sahar Abd El-Sattar. 2004

机译：硝苯地平新型喷雾包衣的软弹性明胶胶囊缓释制剂的开发，维拉帕米盐酸盐控释制剂的生物利用度和生物等效性，在猛禽中单次口服剂量后特比萘芬的药代动力学。
6. Dose-proportional pharmacokinetic properties of GLA5PR GLARS-NF1 controlled-release pregabalin in healthy Korean volunteers: a randomized open single-dose parallel study [O] . Kwang-Hee Shin, Ji-Young Jeon, Kyungho Jang, 2018

机译：GLA5PR GLARS-NF1控释普瑞巴林在健康韩国志愿者中的剂量比例药代动力学特性：一项随机开放单剂量平行研究
7. Selection of 12-Hour Sustained-Release Acetaminophen (Paracetamol) Formulation Through Comparison of Pharmacokinetic Profiles of 4 Sustained-Release Prototype Formulations and Standard Acetaminophen Formulation: An Open-Label, Randomized, Proof-of-Princip [O] . Yong Yue, Dongzhou J. Liu 2017

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8. Pharmacokinetic Study of Perfluorooctanesulfonyl Fluoride (POSF) Following a Single Oral Gavage Dose in Rats [R] . 2004

机译：大鼠单次口服灌胃剂量后全氟辛烷磺酰氟（pOsF）的药代动力学研究

Dose proportionality and pharmacokinetics of carvedilol sustained-release formulation: a single dose-ascending 10-sequence incomplete block study

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