process for the production of a substance or composition, use of the substance or composition, substance or composition, asymmetric sesquiterpene dimer derived therefrom, and method of treatment or prophylaxis of parasitic infections

摘要

PROCESS FOR THE PRODUCTION OF A SUBSTANCE OR COMPOSITION, USE OF THE SUBSTANCE OR COMPOSITION, SUBSTANCE OR COMPOSITION, ASYMMETRIC SQUITERPENE, DERIVATIVE OF THE SAME, AND METHOD OF TREATMENT OR PROPHYLAXIS. The invention provides a process for producing a substance or composition for the treatment, by therapy or prophylaxis, of parasitic infections, in particular of malarial infections such as Plasmodium falci-parum, animal or human body infections. The process comprises extracting the substance or composition from the roots of the plant species Dicoma anomala by extraction using an organic solvent to obtain a liquid extract containing the substance or composition and removing the solvent from the liquid extract to leave a dry extract containing the substance or composition. composition. The invention also extends to the use of the substance or composition in the manufacture of a medicament or preparation for such treatment of infections; a substance or composition for use in such treatment of said infections; the compounds for use in such treatment of said infections; and to a method for treating said infections using such compounds.