Polypeptide that binds specifically to a PDZ domain of the Protein htra1; polynucleotide that encodes; production method; Antibody that binds to and their use to treat diseases; RelationshipThe Protein htra1 adas.

摘要

The invention provides optimized HtrA1 PDZ domain and HtrA3 PDZ domain ligands. The invention further provides modulators of HtrA1 PDZ domain-ligand interaction and HtrA3 PDZ domain-ligand interaction, and methods of identifying and using these modulators.