Topical formulations containing o-desmethylvenlafaxine (ODV) or its Salts.

摘要

The present Invention discloses topical compositions comprising o-desmethylvenlafaxine (ODV), a selective inhibitor of serotonin and norepinephrine, or a pharmaceutically acceptable Salt thereof. In certain embodiments, the present Invention topical formulations containing one or more permucosal / Enhancers of percutaneous absorption.We also present methods for Preparation and use of these compositions for the treatment of various diseases and disorders such as vasomotor symptoms and pain.