SPIRO-HYDANTOIN COMPOUNDS, THEIR USE AS ANTI-INFLAMMATORY AGENTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND INTERMEDIATES FOR PREPARING THEM

摘要

Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L and K are O or S; Z is N or CRSUB4b/SUB; Ar is an optionally-substituted aryl or heteroaryl; G is a linker attached to T or M or is absent; J, M and T are selected to define a three to six membered saturated or partially unsaturated non-aromatic ring; and RSUB2/SUB,RSUB4a/SUB, RSUB4b/SUB, and RSUB4c /SUBare as defined in the specification.