USE OF SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES IN THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF TUMORS ASSOCIATED WITH HIGH LEVELS OF GLUTATHIONE

摘要

Compounds which are alpha-halogenoacryloyl distamycin derivatives of formula (I) wherein RSUB1 /SUBis a bromine or chlorine atom; RSUB2 /SUBis a distamycin or distamycin-like framework as set forth in the specification; or a pharmaceutically acceptable salt thereof; are cytotoxic agents particularly effective in the treatment of tumors over expressing GSH/GSTs system and which are poorly responsive or even resistant to conventional antitumor therapies.