USE OF SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES IN THE TREATMENT OF TUMORS ASSOCIATED WITH HIGH LEVELS OF GLUTATHIONE

摘要

Compounds which are .alpha.-halogenoacryloyl distamycin derivatives of formula(I) wherein R1 is a bromine or chlorine atom; R2 is a distamycin or distamycin-like framework as set forth in the specification; or a pharmaceuticallyacceptable salt thereof; are cytotoxic agents particularly effective in thetreatment of tumors over expressing GSH/GSTs system and which are poorlyresponsive or even resistant to conventional antitumor therapies.