ELECTROCHEMICAL METHODS AND DEVICES FOR USE IN THE DETERMINATION OF HEMATOCRIT CORRECTED ANALYTE CONCENTRATIONS

摘要

;ABSTRACT; Title: Electrochemical methods and devices for use In the determination of hematocrit corrected analyte concentrations. Methods and devices for determining the concentration of an analyte in a physiological sample are provided. In the subject methods, the physioioglcai sample is introduced Into an electrochemical cell having a working and reference electrode. A first electric potential Is applied to the cell and the resultant cell current over a period of time is measured to determine a first time-current transient. A second electric potential of opposite polarity is then applied and a second a time-current transient Is determined. The ppeliminary concentration of the analyte Is then calculated from the first anc|/or second time-current transient This preliminary analyte concentration less a background value Is then multiplied by a hematocrit correction factor to obtain the analyte concentration in the sample, where the hematocrit correction factor is a function of the preliminary analyte concentration and the variable y of the electrochemical cell. The subject methods and devices are suited for use In the determination of a wide variety of analytes In a wide variety of samples and are particularly suited for the determination of analytes in whole blood or derivatives thereof, where an analyte of particular Interest is glucose. Fig: i.