PYRIMIDINE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS.

摘要

The invention provides, compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of Alk, Abl, BRK, Blk, BMX, CSK, c-Src, c-Raf, EGFR, Fes, FGFR3, Fms, Fyn, IGF-IR, IR, IKK??, IKK??, JAK2, JAK3, KDR, Lck, Met, p70S6k, Ros, Rskl, SAPK2??, SAPK2??, SAPK3, SIK, Tie2, TrkB and/or WNK3 kinases.