PIPERIDINE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS.

摘要

Disclosed are novel compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: Msup1/sup and Msup3/sup are CH or N; Msup2/sup is CH, CF or N; Y is -C(=O)-, -C(=S)-, -(CHsub2/sub)subq/sub-, -C(=NORsup7/sup)- or -SOsub1-2/sub-; Z is a bond or optionally substituted alkylene or alkenylene; Rsup1/sup is H, or alkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, all optionally substituted, or a group of the formula (II) where ring A is a heteroaryl ring; Rsup2/sup is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; Rsup3/sup is H, -C(O)NHsub2/sub, or alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl, all optionally substituted; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome, alcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma and cognition deficit disorders using said compounds, alone or in combination with other agents.